Attenuation of Cerebral Ischemia-Reperfusion Injury by Specific Activation of Kv7/KCNQ/M-Channels 

Objective:Stroke is the second common cause of death and a leading causeof adult disability. During ischemic stroke,energy depletion induces anoxic depolarizati...
《神经药理学报》  2019年 第04期 下载次数()| 被引次数()

Oxidative Stress and Antioxidant:What We Should Do for Preventing Brain Damage and Improving Brain Repair in Stroke Treatment 

Free radicals,including reactive oxygen species(ROS) and reactive nitrogen species(RNS),play important roles in ischemic brin injury. However,both ROS and RNS a...
《神经药理学报》  2019年 第Z1期 下载次数(1)| 被引次数()

Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury 

Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and ha...
《Neural Regeneration Research》  2018年 第08期 下载次数(17)| 被引次数(3)

Circular RNA TLK1 aggravates neuronal injury and long-term neurological deficits via miR-335-3p/TIPARP after ischemic stroke 

OBJECTIVE Circular RNAs(circRNAs) are highly expressed in the brain and involved in various central nervous system diseases.However,the potential role of circRN...
《中国药理学与毒理学杂志》  2018年 第09期 下载次数(25)| 被引次数(1)

Molecular chaperones and hypoxic-ischemic encephalopathy 

Hypoxic-ischemic encephalopathy(HIE) is a disease that occurs when the brain is subjected to hypoxia,resulting in neuronal death and neurological deficits,with ...
《Neural Regeneration Research》  2017年 第01期 下载次数(32)| 被引次数(14)

Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a 

Ischemic postconditioning renders brain tissue tolerant to brain ischemia,thereby alleviating ischemic brain injury.However,the exact mechanism of action is sti...
《Neural Regeneration Research》  2016年 第04期 下载次数(4)| 被引次数(9)

Regulation of mitophagy in ischemic brain injury 

The selective degradation of damaged or excessive mitochondria by autophagy is termed mitophagy. Mitophagy is crucial for mitochondrial quality control and has ...
《Neuroscience Bulletin》  2015年 第04期 下载次数(50)| 被引次数(7)

Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury 

One of the most important causes of brain injury in the neonatal period is a perinatal hypoxicischemic event.This devastating condition can lead to long-term ne...
《Neural Regeneration Research》  2013年 第08期 下载次数(22)| 被引次数(0)

Ischemic preconditioning reduces ischemic brain injury by suppressing nuclear factor kappa B expression and neuronal apoptosis 

Ischemic stroke induces a series of complex pathophysiological events including blood-brain barrier disruption, inflammatory response and neuronal apoptosis. Pr...
《Neural Regeneration Research》  2013年 第07期 下载次数(9)| 被引次数(3)

Neuroprotective effects of LBP on brain ischemic reperfusion neurodegeneration 

OBJECTIVE The present study was conducted to investigate whether LBP had a protective effect on cerebral ischemic reperfusion injury and to determine the possib...
《中国药理学与毒理学杂志》  2012年 第03期 下载次数(28)| 被引次数(0)

Protective effects of acupuncture on brain tissue following ischemia/reperfusion injury 

BACKGROUND: In patients with cerebrovascular disease, by means of the neuroendocrine system, acupuncture supports the transformation of a local pathological sta...
《Neural Regeneration Research》  2008年 第03期 下载次数(80)| 被引次数(4)

Cerebral organoids repair ischemic stroke brain injury 

OBJECTIVE Stroke is the second leading cause of death and main cause of disability worldwide,but with few effective therapies. Although stem cellbased therapy h...
《中国药理学与毒理学杂志》  2019年 第10期 下载次数(0)| 被引次数(0)

Attenuation of cerebral ischemia-reperfusion injury by specific activation of Kv7/KCNQ/Mchannels 

OBJECTIVE To test any neuroprotective effect of KCNQ channel openers on ischemic injury in mice. METHODS Mouse model of ischemic-reperfusion(I/R) was establishe...
《中国药理学与毒理学杂志》  2019年 第10期 下载次数(0)| 被引次数(0)

Ligustroflavone reduces necroptosis in rat brain after ischemic stroke through targeting RIPK1/RIPK3/MLKL 

OBJECTIVE To explore the effect of ligustroflavone on ischemic brain injury in stroke rat and the underlying mechanisms. METHODS A rat model of ischemic stroke ...
《中国药理学与毒理学杂志》  2019年 第09期 下载次数(5)| 被引次数(0)

血糖异常对脑组织的损伤以及相关机制研究 

背景临床研究证实,血糖异常(包括低血糖、高血糖和血糖波动)与脑损伤之间存在着密切的相关性。葡萄糖是大脑的主要能量来源,其水平的升高、降低或波动均会影响神经功能,造成不同程度的脑损伤。急性严重低血糖会直接导致脑组织损伤;而高血糖和血糖波动会加重缺血性脑损伤,临床上常将高血糖和血糖波动视为缺血性卒中的危险因素。下面将分别阐...
上海交通大学  博士论文  2018年 下载次数(17)| 被引次数()

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