Specific or General Base Catalysis? A DFT Study on the Mechanism of Phosphodiester Cleavage Promoted by Dinuclear Zn(Ⅱ) Complex 

As the back-bone of DNA and RNA,phosphodiesters play a fundamental role in living systems.Some metal-complex can interact with phosphodiester to change and a...
第十届全国计算(机)化学学术会议论文摘要集  2009-10-23 下载次数(8)| 被引次数(0)

Cleavage of DNA by a New Mixed-ligand Cu(Ⅱ) Complex 

Cleavage of DNA pUC19 by [Cu(saldien)(NH3)]Cl2 (here, saldien=bis(salicylicdene)- diethylenetriamine) was investigated at different pHs, times, concentrations,...
《Chinese Chemical Letters》  2005年 第01期 下载次数(32)| 被引次数(1)

Hfq bridged ternary complex is important for translation activation of rpoS by DsrA 

The rpoS mRNA, which encodes the master regulator σS of general stress response, requires Hfq facilitated base-pairing with DsrA small RNA(sRNA) for translation...
第四届中国结构生物学学术讨论会论文摘要集  2013-03-31 下载次数(6)| 被引次数(0)

Transmembrane protein VSD is required for axon crossing for the formation of central complex 

Objective Neuronal connections between the hemispheres are considered important for organisms to organize information to adapt to variable environments.In ce...
中国神经科学学会第九届全国学术会议暨第五次会员代表大…  2011-07-29 下载次数(5)| 被引次数(0)

A KINETIC STUDY ON DISMUTATION OF SUPEROXIDE ANION BY A NOVEL SUPEROXIDE DISMUTASE MIMIC BIS(DIOXOTETRAAMINE) COPPER(Ⅱ) COMPLEX USING PULSE RADIOLYSIS 

Themajorfunctionofsuperoxidedismutase(SOD)istocatalyzethedismutationofsuperoxideanion(·O-2)andcontrolintracellularandextracell
《南京大学学报(自然科学版)》  1999年 第05期 下载次数(14)| 被引次数(0)

Structural Basis of Pre-m RNA Splicing 

Splicing of precursor messenger RNA(pre-m RNA), involving removal of the non-coding introns and ligation of neighboring exons, is a defining feature for all euk...
中国生物化学与分子生物学会2016年全国学术会议论文集  2016-10-20 下载次数(44)| 被引次数(0)

蛋白质和DNA以及蛋白质和蛋白质的分子动力学模拟研究 

1977年,McCammon JA等人报道了第一个蛋白质的分子动力学模拟,这开启了生物物理领域中“从结构到功能”研究的新纪元。分子动力学模拟提供了生物大分子运动的详细信息,并且可以帮助揭示生物大分子在众多生理过程中所扮演的重要角色。例如蛋白与配体的结合过程,酶催化过程等多种重要的分子生物学过程。并且分子动力学模拟可以为...
南京大学  博士论文  2013年 下载次数(1299)| 被引次数(3)

Inhibition of Qi and Qo sites of mitochondrial complexⅢinduced opposite effects on HVA calcium channels via activation of different protein kinase C isoforms in cortical neurons 

Objective Inhibition of Qi and Qo sites of mitochondrial complexⅢunder hypoxia and ischemia has received attention,but its downstream targets remain largely ...
Proceedings of the 8th Biennial Conference of the Ch…  2009-11-07 下载次数(4)| 被引次数(0)

Studies on Bursting Transition in a Two-coupled Cell Network within the Pre-Btzinger Complex 

The pre-Botzinger complex of the mammalian brain stem has been discovered to play a crucial role in the generation of respiratory rhythms.Excitatory neurons wit...
第十五届全国非线性振动暨第十二届全国非线性动力学和运…  2015-05-08 下载次数(3)| 被引次数(0)

RACK1,a Novel Component of β-catenin Destruction Complex,Negatively Regulates Wnt/β-catenin Signaling 

Wnt/β-catenin signaling participates in virtually every aspect of embryonic development,and aberrant Wnt/B-catenin signaling transductions are involved in ma...
第三届细胞结构与功能的信号基础研讨会论文摘要  2010-05-14 下载次数(20)| 被引次数(0)

RapidRNAi in Xenopus early embryo by Ago2/siRNA complex 

Xenopuslaevis is a popular and versatile model organismto study early embryonic development,especially the contribution of maternal regulation.However,the us...
2012全国发育生物学大会摘要集  2012-10-21 下载次数(6)| 被引次数(0)

The mechanism of the SNARE complex assembly regulated by Munc18-1 and Munc13-1 

The SNARE complex involved in neurotransmitter release is composed of synaptobrevin on the synaptic vesicles,and syntaxin-1 and SNAP-25 on the plasma membran...
中国生物化学与分子生物学会第十一次会员代表大会暨2014…  2014-08-21 下载次数(19)| 被引次数(0)

Experimental Studies on immune-Complex in Situ Type Glomerulonephritis in Rabbits Treated with Mai-Luo-Tong and Natural Indig 

(孙世澜)(易惠萍)(汪琼玲)(黄寿珍)(刘晓城)ExperimentalStudiesonimmune-ComplexinSituTypeGlomerulonephritisinRabbitsTreatedwithMai-Luo-TongandNatural...
《同济医科大学学报》  1994年 第03期 下载次数(18)| 被引次数(0)

Macalpinomyces eriachnes represents a complex of cryptic species 

Macalpinomyces eriachnes,is a monotypic species of smut fungus endemic to Australia.It is the type species of Macalpinomyces.In our study,combined morphological...
中国菌物学会第六届会员代表大会(2014年学术年会)暨贵…  2014-07-14 下载次数(9)| 被引次数(0)

Uncover the myths of voltage-gated sodium channels: cryo-EM structure of the EeNa_v1.4-β1 complex 

Ion channels are membrane-embedded macromolecular pores,which allow charged ions flow through the insulating lipid bilayer when channel pores are opened.The ...
《Science Bulletin》  2017年 第19期 下载次数(8)| 被引次数()

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