Syntheses of novel bioactive Natural Product-like Compounds based on Diversity-Enhanced Reactions 

The success of future drug discovery heavily relies on the sustainable identification of new chemical entities.Quick synthesis of skeletally diverse natural pro...
中国化学会全国第十二届有机合成化学学术研讨会论文摘要…  2015-10-15 下载次数(1)| 被引次数(0)

高速逆流色谱法分离纯化黄顶菊及芒果花中活性成分及活性研究 

入侵植物可以产生有各种医药功能的代谢产物。我们实验室曾经研究建立了简单而成功的分析方法来鉴定有用的目标黄酮类成分,这是获得入侵植物的提取物中有效成分的重要一步。建立了制备分离十种总黄酮的方法。选择D4020树脂,因为它具有高吸附和解吸能力。根据以下优化的参数进行动态吸附/解吸过程:黄顶菊提取物浓度为2.72mg/mL,...
北京化工大学  博士论文  2017年 下载次数(132)| 被引次数()

Dimer-Based 3D-QSAR Studies of Novel Analogues of Neonicotinoids:the roles of molecular aggregation state of bioactive compounds with water 

Water molecules have been found can bridge the binding of compounds with targets through hydrogen bonding networks in many binding sites.In other word,these ...
2011年全国药物化学学术会议——药物的源头创新论文摘要…  2011-11-17 下载次数(3)| 被引次数(0)

唑类活性小分子的合成与抗微生物活性研究及其血清白蛋白的相互作用 

血清白蛋白是血浆中含量最丰富的载体蛋白,它可以与许多内源性和外源性物质结合,在体内起存储和转运作用。药物进入血液,先与血清白蛋白结合,被它储存、转运,才能到达受体部位发挥药效作用。一些有成药希望的活性小分子因与血清白蛋白有过强或过弱的亲和力,从而限制了其成为临床药物。因此研究生物活性小分子与血清白蛋白的相互作用,不仅有...
西南大学  硕士论文  2013年 下载次数(132)| 被引次数(1)

Cell Affinity Capture and HPLC-MS Analysis for Anticardiovascular Diseases Drug Screening from Danshen 

This manuscript develops a novel high-throughput analysis and screening method of cell affinity capture coupled with HPLC-mass spectrometry analysis(CAC-HPLC-MS...
第二十届全国色谱学术报告会及仪器展览会论文集(第三分…  2015-04-19 下载次数(7)| 被引次数(0)

Novel Bioactive Compounds from Some Chinese Marine and Terrestrial Plants 

Discoveries for the advancement of medicine and understanding of life sciences constitute one of the most powerful ways in whic
中国化学会第二十五届学术年会论文摘要集(下册)  2006-07-01 下载次数(1)| 被引次数(0)

Radiation Parameters of Some Potential Bioactive Compounds 

In this study,we aimed to determine the radiation parameters of some potential bioactive compounds.1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type Mannic...
《光谱学与光谱分析》  2015年 第06期 下载次数(13)| 被引次数(0)

Tertiary Enamides Are Unique Building Blocks in the Synthesis of Natural and Unnatural Bioactive N-Heterocyclic Compounds 

Enamides are enamine variants that are stable and occur as natural products.Due to the electronic effect of an electron-withdrawing group on nitrogen,the del...
中国化学会第十届全国有机合成化学学术研讨会会议论文集  2012-08-01 下载次数(7)| 被引次数(0)

Chemo-enzymatic Synthesis of Bioactive Compounds 

As the readily available synthetic intermediates,nitriles have been extensively used to prepare carboxylic acids and amide deri
中国化学会第二十五届学术年会论文摘要集(上册)  2006-07-01 下载次数(0)| 被引次数(0)

Developing polymeric micelles for cancer targeted theranostics 

Polymeric micelles are generally constructed with a protecting shell of a hydrophilic polymer for shelling the hydrophobic core, demonstrating high performance ...
中国化学会2017全国高分子学术论文报告会摘要集——主题…  2017-10-10 下载次数(6)| 被引次数()