The Effect of activated charcoal hemoperfusion on renal function in paraquat poisoning patients 

Introduction:The application of activated charcoal hemoperfusion accelerated the removal of PQ from the blood.However,there are no reports focus on the effect o...
2016中国中毒救治首都论坛——暨第八届全国中毒及危重症…  2016-06-17 下载次数(4)| 被引次数(0)

吡格列酮通过PPARγ抑制CXCR7表达进而抑制人巨噬细胞趋化性 

二型糖尿病患者在致死或者非致死的大血管事件中都具有很高的危险,包括冠状动脉粥样硬化或者脂肪沉淀性的血管粥样硬化。在患有二型糖尿的病人中,动脉粥样硬化是主要的致死因素[14]。大血管的动脉粥样硬化常常伴随着糖尿病的发展,而且这两种疾病有很多相同的致病因素,包括遗传和环境等因素[15]。在临床实践中,噻唑烷二酮类药物以及吡...
吉林大学  博士论文  2016年 下载次数(312)| 被引次数(0)

Central nesfatin-1 activated lipid mobilization in adipose tissue and fatty acid oxidation in muscle through sympathetic nervous system 

Objective:Nesfatin-1,an anorexigenic peptide involved in energy homeostasis.Recently,peripheral nesfatin-1 was reported to participate in the development of T2D...
中国生理学会第24届全国会员代表大会暨生理学学术大会论…  2014-10-24 下载次数(10)| 被引次数(0)

活性炭肠道驱铅治疗铅中毒的实验研究 

研究背景现代城市化和工业化对环境的污染,不仅使我国人们血铅水平远远高于西方发达国家,而且铅中毒的特征也发生了变化。铅中毒的特征由过去急性铅中毒为主的职业病逐渐转变为血铅轻度超标为主的流行病,严重影响儿童的生长发育和人们的身体健康水平。目前国内外对铅中毒研究进展缓慢,临床治疗药物主要还是络合剂,它与铅离子形成无...
中南大学  博士论文  2007年 下载次数(459)| 被引次数(9)

Peroxisome proliferator-activated receptor-delta in metabolic syndrome:special emphasis on vessel and liver 

Emerging evidence has revealed potential implications of peroxisome proliferator-activated receptor-δ(PPAR-δ) in lipid homeostasis,insulin resistance and car...
中国病理生理学会受体和信号转导专业委员会暨消化专业委…  2008-11-01 下载次数(10)| 被引次数(0)

The systemic protective function of PD-1-PD-L1-Ig attenuates the autoimmune injure of lupus-like nephritis in systemic lupus erythematous model 

Objective: PD-L1(programmed death ligand) is a member of the B7 family of costimulatory molecules that specifically interacts with programmed death 1(PD-1) expr...
第十一届全国免疫学学术大会摘要汇编  2016-11-04 下载次数(21)| 被引次数(0)

Effects of the peroxisome proliferator activated receptor-γcoactivator-1α(PGC-1α) Thr394Thr and Gly482Ser polymorphisms on rosiglitazone response in Chinese patients with type 2 diabetes mellitus 

Our objective was to investigate if PGC-1αThr394Thr and Gly482Ser polymorphisms influence rosiglitazone response in Chinese T2DM patients. Among the 241 pati...
湖南省首届生理—药理科学青年论坛论文摘要汇编  2009-11-14 下载次数(10)| 被引次数(0)

Peroxisome proliferator-activated receptor delta+294T>C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations 

Objectives The association of peroxisome prolif-erator -activated receptor delta(PPARD) +294TC polymorphism and serum lipid levels is inconsistent in severa...
《岭南心血管病杂志》  2011年 第S1期 下载次数(16)| 被引次数(0)

Association of peroxisome proliferator-activated receptor single-nucleotide polymorphisms and gene-gene interactions with the lipoprotein(a) 

Objective To examine the associations of 10 singlenucleotide polymorphisms(SNPs)in peroxisome proliferator-activated receptor(PPARs)gene with lipoprotein(a)l...
《China Medical Abstracts(Internal Medicine)》  2014年 第03期 下载次数(14)| 被引次数(0)

TLR3 upregulation of fibroblast-like synoviocytes activated by T cells modulates articular inflammation of pristane-induced arthritis in rats 

Rheumatoid arthritis(RA) is a chronic articular inflammation involved with an abnormal immune response.Tolllike receptors(TLRs),as a kind of important patter...
中国生物化学与分子生物学会第十届会员代表大会暨全国学…  2010-08-23 下载次数(1)| 被引次数(0)

Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-Fat Diet 

Objective To investigate activation of brown adipose tissue(BAT)stimulated by medium-chain triglyceride(MCT).Methods 30 Male C57BL/6J obese mice induced by fed ...
第十四届全国临床营养学术会议资料汇编  2014-10-20 下载次数(6)| 被引次数(0)

活性炭对常见化学物经口中毒的疗效评价研究 

我国的突发化学物经口中毒事件危害严重,如在患者中毒早期的毒物清除措施较为得当,将可降低病死率。其中口服活性炭因其吸附效能好、不良反应少、给药方便等优点,在国外常被作为毒物经口中毒早期最重要的清除措施。目前存在的问题是,国内外尚无评价其吸附效能相关系统综述或大样本RCT的文献报道,因此无法肯定化学物,特别是常...
中国疾病预防控制中心  硕士论文  2008年 下载次数(95)| 被引次数(3)

The mechanism of T lymphocyte differentiation in nonobese diabetic(NOD) mice regulated by peroxisome proliferator-activated receptors 

The peroxisome proliferator-activated receptors(PPARS) are a family of transcription factors belonging to the nuclear receptor superfamily.Recently an immuno...
中国生物化学与分子生物学会第十届会员代表大会暨全国学…  2010-08-23 下载次数(2)| 被引次数(0)

Structural insight into the regulation of AMP-activated protein kinase 

The AMP-activated protein kinase(AMPK),conserved in all eukaryotic species,plays a central role in regulating cellular metabolism and energy homeostasis by s...
中国生物化学与分子生物学会第十届会员代表大会暨全国学…  2010-08-23 下载次数(2)| 被引次数(0)

硫化氢对2型糖尿病脂代谢的作用及其机制 

硫化氢(hydrogen sulfide, H2S)是一种有强烈臭鸡蛋气味的无色气体,它一直被人们认为是毒性气体。直到1989年,科学家在大鼠和人脑中检测到了内源性的H2S,提示H2S可能具有一定的生理作用。随着对H2S研究的深入,发现内源性H2S对心血管系统、消化系统、神经系统和免疫系统均有重要的生理调节功能,如它可...
复旦大学  博士论文  2011年 下载次数(386)| 被引次数(3)

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