Genetic diagnosis of lymph-node metastasis in colorectal cancer 

The presence of metatatic tumor in regional lymph nodes at the time of colorectal surgery is of major significance for tumor recurrence and prognosis in pati...
第六次全国大肠癌会议暨中日韩大肠癌会议论文汇编  1998-09-01 下载次数(6)| 被引次数(0)

Reduced expression and genetic alterations of ING4 in human stomach adencarcinoma 

As a member of ING gene family which harbor the PHD domain and NLS domain,ING4 was reported to interact with tumor suppressor p53 and found to be involved in...
中国遗传学会第八次代表大会暨学术讨论会论文摘要汇编(…  2008-10-01 下载次数(10)| 被引次数(0)

A search for genetic factors associated with MLH1 promoter methylation in human endometrial and colorectal cancer 

在子宫内膜癌和大肠癌,DNA 错配修复功能缺陷的常见原因为 MLH1基因的表观遗传沉默.我们假设 MLH1基因的多态性与 MLH1甲基化和表观遗传沉默的发生风险有关.为了验证此假说.运用对照研究检测 MLH1多态性与 MLH1 甲基化的关联情况.10个 MLH1单核苷病例酸多态性(SNP)被用于子宫内膜(EC)癌...
遗传学进步与人口健康高峰论坛论文集  2007-11-01 下载次数(28)| 被引次数(0)

The genetic variants of Fas/FasL genes are associated with epithelial ovarian cancer susceptibility and outcome 

Aim:The Fas/FasL system has been suggested playing an important role in tumorigenesis and progression of cancer patient.In this study,we evaluated whether the f...
遗传学进步促进粮食安全与人口健康高峰论坛论文集  2012-08-14 下载次数(10)| 被引次数(0)

基于表达数量性状位点(eQTL)定位分析策略的结直肠癌遗传易感性研究 

研究背景结直肠癌(colorectal cancer, CRC)是当今全球第三大恶性肿瘤,严重威胁人类的健康。2015年我国CRC新发病例37.6万例,死亡病例19.1万例,五年生存率仅为44%左右,CRC已成为我国当前亟待解决的重大公共卫生问题之一,而其发病率和死亡率居高不下的根本原因在于对其生物学病因机制缺乏突破性...
华中科技大学  博士论文  2016年 下载次数(663)| 被引次数(1)

Risk of Genome-Wide Association Study-Identified Genetic Variants for Non-Hodgkin lymphoma in a Chinese Population 

Background Recent genome-wide association studies have identified 12 single nucleotide polymorphisms(SNP) associated with the Non-Hodgkin lymphoma subtypes i...
全国肿瘤流行病学和肿瘤病因学学术会议论文集  2011-07-01 下载次数(10)| 被引次数(0)

Association of p14ARF genetic variants with HPV16-positive oropharyngeal cancer and survival 

BACKGROUND Given the roles of pl4ARF and HPV16 E6/E7 oncoproteins as either an activator or negative regulator in the p53/Rb pathways,we hypothesized that pl...
全国耳鼻咽喉头颈外科中青年学术会议论文汇编  2012-10-25 下载次数(6)| 被引次数(0)

The Genetic Epidemiology of Lung Cancer-What have we learned? 

With the completion of the Human Genome Project new opportunities have been arisen to more fully characterize the genomic factor contributing to human suscep...
《Journal of Nanjing Medical University》  2008年 第02期 下载次数(15)| 被引次数(0)

Genetic Analysis of 477 Patients with de novo Acute Myeloid Leukemia 

Background:To improve and validate the detection of clonal chromosomal aberrations in leukemias,we designed a combined application of karyotyping with multip...
第13届全国实验血液学会议论文摘要  2011-11-24 下载次数(9)| 被引次数(0)

Reduced Expression and Genetic Alterations of ING4 in Human Stomach Adencarcinoma 

ING4 is a member oflNG gene family and harbors the PHD domain and NLS domain.ING4 is reported to interact with tumor suppressor p53 and found to be involved ...
中国遗传学会“发育、遗传和疾病”研讨会论文汇编集  2007-08-01 下载次数(6)| 被引次数(0)

Genetic dissection of key signaling pathways in BCR-ABL leukemogenesis:the role of Src family kinases. 

Human Philadelphia chromosome-positive (Ph~+) leukemias induced by the BCR/ABLoncogene, including chronic myeloid leukemia (CML) and B-cell acute lymphoblas...
中国细胞生物学学会第八届会员代表大会暨学术大会论文摘…  2003-11-01 下载次数(8)| 被引次数(0)

No interactions between FGFR2 genetic polymorphisms and reproductive factors in breast cancer among Chinese women 

Background Fibroblast growth factor receptor 2(FGFR2) gene has been associated with the risk of breast cancer in multiple ethnic populations,and its effect h...
全国肿瘤流行病学和肿瘤病因学学术会议论文集  2011-07-01 下载次数(10)| 被引次数(0)

Oncofertility in adolescent and young adult hereditary cancer: Considerations for genetics professionals 

Adolescents and young adults(AYA)with a cancer diagnosis or those at risk for cancer due to hereditary cancer syndromes may benefit from genetic counseling and ...
《World Journal of Medical Genetics》  2015年 第04期 下载次数(2)| 被引次数(0)

中国人群膀胱癌遗传易感性及其机制研究 

膀胱癌是全球常见的泌尿系统恶性肿瘤,其中90%以上为移行上皮细胞癌。在我国泌尿系统肿瘤中,无论是发病率还是死亡率,膀胱癌均占据首位。膀胱癌的发生和发展是一个多基因、多因素参与的多阶段的过程,是环境因素和遗传因素共同作用的结果。流行病学调查显示,吸烟和职业暴露是膀胱癌最常见的环境因素,但同时也发现,尽管很多人接触相同的危...
南京医科大学  博士论文  2010年 下载次数(843)| 被引次数(2)

FoxP3 genetic variants and risk of non-small cell lung cancer in the Chinese Han population 

Background and objective:CD4~+CD25~+ regulatory T cell-mediated immunosuppression is one of the crucial mechanisms that tumor cells use to evade the immune s...
第13届全国肺癌学术大会论文汇编  2013-08-08 下载次数(30)| 被引次数(0)

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