Fast and effective target identification of the bioactive compounds form the medicinal plants via computational chemical biology approach 

The potential drug target database(PDTD) was searched by TarFisDock server,a reverse docking approach,to identify putative targets for a collection of 19 nat...
2011年全国药物化学学术会议——药物的源头创新论文摘要…  2011-11-17 下载次数(8)| 被引次数(0)

基于肠道菌群探讨中药的活性成分及效应物质发现 

随着现代慢性复杂性疾病发病率的攀升以及中医药在治疗慢性病方面的优势日益凸显,中药的国内外地位与日俱增。而中药活性成分、效应物质及相应作用机制的未知性极大限制了中药的临床接受度与国际化进程。发现直接关切中药药效的活性成分及效应物质是中药研究的关键科学问题之一。在回顾目前中药活性成分发现模式的基础上,跟踪国际研究前沿,结合...
《中草药》  2020-04-02 11:28 下载次数(0)| 被引次数(0)

唑类活性小分子的合成与抗微生物活性研究及其血清白蛋白的相互作用 

血清白蛋白是血浆中含量最丰富的载体蛋白,它可以与许多内源性和外源性物质结合,在体内起存储和转运作用。药物进入血液,先与血清白蛋白结合,被它储存、转运,才能到达受体部位发挥药效作用。一些有成药希望的活性小分子因与血清白蛋白有过强或过弱的亲和力,从而限制了其成为临床药物。因此研究生物活性小分子与血清白蛋白的相互作用,不仅有...
西南大学  硕士论文  2013年 下载次数(132)| 被引次数(1)

Antioxidant activity and the bioactive compounds of methanol extracts of white jelly mushroom,Tremella fuciformis 

White jelly mushroom(Tremella fuciformis) has been used in traditional China medicine.The following antioxidant activities of subfractions from the methanol ...
中国菌物学会第五届会员代表大会暨2011年学术年会论文摘…  2011-08-15 下载次数(24)| 被引次数(0)

Chemical diversity and the bioactive compounds from marine invertebrates inhabited in South China Sea 

China holds a long coastline(approximately 18,000 km) and covers three different climatic zones ranging from temperate to tropical regions.Its coastal waters...
中国化学会第9届天然有机化学学术会议论文集  2012-11-08 下载次数(33)| 被引次数(0)

LDH-A inhibitory activity guided isolation of bioactive compounds from Spatholobus suberectus 

Objective:To screen out the potential LDH-A(Lactate dehydrogenase A,a novel potential molecular target for cancer therapy) inhibitors from Spatholobus subere...
中国化学会第9届天然有机化学学术会议论文集  2012-11-08 下载次数(12)| 被引次数(0)

从海藻和植物中发现抗菌和抗肿瘤活性化合物 

目前,新药尤其是抗生素,急切需要解决病原体抗性的问题,其中大自然拥有最丰富的新抗生素来源,因此,从天然资源中寻找具有显著生物活性的天然产物仍然是发现新药先导化合物的主要途径。此外,抗生素在生物工程合成领域和化学合成领域也有相当大的进步。海洋为海洋生物提供了巨大而多样的栖息地。海洋因其具有不断变化的温度,压力,盐度和金属...
浙江大学  博士论文  2018年 下载次数(211)| 被引次数(1)

Separation, Identification and Evaluation of Different Extracts of Polygonum Bistorta L. for Bioactivity 

Polygonum bistorta L.(quan shen) belongs to family Polygonaceae and is one of the strongest traditional herb astringents that have been used around the world fo...
华东理工大学  博士论文  2012年 下载次数(90)| 被引次数(0)

Anticancer activity of medicinal mushroom Cordyceps taii and its bioactive compounds 

Cordyceps taii is a folk medicinal mushroom native to south China,and was described and identified as a new Cordyceps species in the 1990s.In vivo test showe...
中国化学会第十届全国天然有机化学学术会议论文集——第…  2014-11-21 下载次数(1)| 被引次数()

In Vivo Screen Strategies for Discovering Bioactive Compounds Against Cerebrovascular and Neurodegenerative Diseases 

Cerebrovascular and neurodegenerative diseases are tightly associated with each others and are increasing harmful to our health and life.The global disease p...
第十四届全国中药和天然药物学术研讨会论文摘要  2014-08-26 下载次数(3)| 被引次数(0)

Screebubg if actuve cinibebts in Angelica sinensis by using biomembrane affinity extraction coupled with high performance liquid chromatography 

ABSTRACTThe screening and analysis of bioactive components in tradifional Chinese medicines (TCMs) is very important not orly forthe quality control of crude...
中国药理学会制药工业专业委员会第十一届学术会议论文摘…  2004-06-30 下载次数(9)| 被引次数(0)

ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM ENDOPHYTES ASSOCIATED WITH MEDICINAL PLANTS 

In the field of natural products,plants have proven their interest as a source of lead compounds in drug discovery.Nevertheless,in the context of biodiversit...
《World Journal of Traditional Chinese Medicine》  2015年 第04期 下载次数(4)| 被引次数()

Bioactive Diphenyl Ether Derivatives from a Marine-Derived Talaromyces sp.Fungus 

Marine-derived fungi have proven to be rich sources of structurally novel and biologically active secondary metabolites for drug discovery.There have been an in...
全国第九届海洋生物技术与创新药物学术会议论文摘要集  2014-08-06 下载次数(12)| 被引次数(0)

GC–MS analysis of bioactive compounds present in different extracts of an endemic plant Broussonetia luzonica (Blanco) (Moraceae) leaves 

Objective: To investigate and characterize the chemical composition of the different crude extracts from the leaves of Broussonetia luzonica(Blanco)(Moraceae)(B...
《Asian Pacific Journal of Tropical Biomedicine》  2016年 第11期 下载次数(9)| 被引次数(1)

超声在梨汁加工中的应用 

梨(Pyrus bretschneideri R.)是产量较大的温带水果,仅次于葡萄及苹果。其中,中国的梨产量占世界产量的70%以上。在中国,梨作为传统药物使用已有2000多年历史,具有抗炎、抗高血糖及利尿等功效。相比苹果,梨具有较低的钠含量、较高的钾含量及低酸性性质使其成为高酸性食品及婴儿食品的常见成分。热处理是食品...
南京农业大学  博士论文  2016年 下载次数(62)| 被引次数()

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